Taste Masking

Drug resinates are insoluble hence, even resinate of bitter drugs have virtually no taste. With the correct selection of the ion exchange resin, the drug is not released in the mouth so that the patient does not taste the drug when it is swallowed. When the drug resinate comes into contact with the gastrointestinal fluids, such as the acid of the stomach, the drug is released from the resinate, directly into solution and then absorbed in the usual way. The resin passes through the GI tract without being absorbed.

Examples of drugs where this technique has been successfully demonstrated include ranitidine and paroxetine. 

Dow has also developed a novel Buccal Dissolution System to test the taste masking efficiency of oral dosage forms.

 

Products Guidelines

Drugs with cationic functionality (e.g. -COOH or Na / K salts) 

DUOLITE™ AP143.

Drugs with anionic functionality (-NH₂, HCl salts etc.)

AMBERLITE™ IRP64, AMBERLITE™ IRP69

References:

Amberlite IRP64

• Douglas, S.J. Glaxo Group Research Ltd, 1990. Process for the preparation of a ranitidine resin absorbate. EP 0 431 759.
• Astruc, J., and A. Sambot, 1970. Ion-exchange resin: spiramycin compositions. Patent GB 1,180,233.
• Borodkin, S., and D.P. Sundberg, 1971. Chewable tablets including coated particles of psuedo-ephedine-weak cation exchange resin. Patent US 3,594,470.

Amberlite IRP69

• Martel, J., J. Tessler, P. Girault, and P. Grandadam., 1981. Acid type ion exchange resins and their use as medicines and compositions containing them. Patent EP 27,768.
• Quinlan, J. M., 1980. Diethylcarbamazine resinate and Strylpyridinium resinate-diethylcarbamazine resinate edible anthelmintic tablets for companion animals. Patent GB 2,055,575.

 

 

Related Information

Taking the Yeuch out of Medicine

Abstract:

Everyone knows that medicines taste bad and that this can lead to poor patient compliance. As the pharmaceutical industry expands the use of dosage forms such as liquids and fast-melts, this problem increases in importance. In this presentation Dr. Hughes will review methods for reducing the objectionable taste of medicines. Technologies covered will include coating, flavoring, ion exchange resins, and others. (Download presentation - pdf: 235 KB).

Ion Exchange Resins in Drug Delivery

Abstract: Ion exchange resins have been used commercially in drug delivery for many years, but the technology is not widely known within the healthcare and related industries. This presentation will describe the uses of these materials for extended release, taste masking and reduce abuse formulations. In addition to covering their use in existing commercial applications it will also include new insights into their use that provide new opportunities to control the release of active ingredients.

Making Medicines Taste Better

(PMPS) - Available online